Cytoplasmic TDP-43 aggregates shows both EGFP and DsRed fluorescence (arrow). were transduced with AxDsR-WT.TDP43 and AxDsR-CTF.TDP43 (DsR-(WT+CTF)) (red) followed by the treatment with DMSO (a), 0.5 M MG-132 (b), or 1 M lactacystin (c) for 24 hrs. Fixed cells were immunostained with phosho-TDP-43 (pS409/S410) (green) and TuJ1 (white) and counterstained with Hoechst 33342 (blue). Arrows … Continue reading Cytoplasmic TDP-43 aggregates shows both EGFP and DsRed fluorescence (arrow)